Anhui Medipharm Co.,Ltd. |
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Chloramphenicol Capsule 250mg
Detailed Product DescriptionPharmacological action:
Chloramphenicol is a broad spectrum antibiotic effective against a
wide range of Gram-negative and Gram-positive
bacteria,rickettsias,and chlamydias.It acts by interfering with
bacterial protein synthesis and is mainly
bacteriostatic.Chloramphenicol is active when given orally and
diffuses into the cerebrospinal fluid even when the meninges are
not inflamed.The majority of a dose is inactivated in the
liver,only a small proportion appearing unchanged in the urine.
Indications:
Typhold fever and other types of systemic salmonella infections.The
carrier state will not be eliminated.Bacterial meningitis due to
haemophilus influenzae.Anaerobic infections originating from foci
in the bowel peivis.Rickettsial diseases such as
epidemic,murine,scrub and recrudescent typhus.Rocky Mountain
spotted fever and Q.fever when tetracyclines are not indicated.
Brucellosis when tetracyclines are contra-indicated.
The use of chloramphenicol should be limited to serious infections
where positive bacteriological evidence and clinical judgement
indicates that chloramohenicol is an appropriate antibiotic.
Contra-indications:
Chloramphenicol in contra-indicated in the following conditions:
Warnings:
The risk of aplastic anaemia does not restrict the use of
chloramphenicol in situations in which it is necessary;however,it
emphasizes that the drug should never be employed in diseases
readily,safely and effectively treatable with other antimicrobial
agents or in undefined cases.
The use of chloramphenicol during pregnancy is best avoided.
Repeated courses and prolonged treatment should be avoided.
Concomitant administration of chloramphenicol with other drugs
liable to depress bone-marrow function should be avoided.
Chloramphenicol enhances the effects of coumarin
anticoagulants,some hypoglycaemic agents (chlorpropamide and
tolbutamide) and phenytoin.
Dosage and Administration:
Adults:-500mg every 6 hours or 50mg/kg body mass daily in divided
doses every 6 hours.
The dose of chloramphenicol should be reduced in the presence of
hepatic disease or in patients with renal insufficiency.
Children:-25 to 50 every 6 hours or 50mg/kg body mass daily,given
in divided doses at intervals of 6 hours.
Storage instructions:
Store below 25 degrees and protect from light. Keep out of reach of
children.