COVID 19 Neutralizing Antibody Rapid Diagnostic Cassette NAb 15mins Reading

COVID-19 Neutralizing Antibody One Step Rapid Diagnostic Cassette Test after Vaccination

² Fast: 15 Minutes

² Specimen: Serum/Plasma/Whole Blood or Fingertip Blood.

² Usage: Detection of Neutralizing (NAb) that blocks RBD-ACE2 interaction.

² Cheap: Lower cost with high efficiency

【PRODUCT NAME】

COVID-19 (2019-nCoV) Neutralizing Antibody Test Kit

(Colloidal Gold method)

【MAIN CONTENTS OF NEUTRALIZING ANTIBODY】

Test cassette with desiccant.

Sample buffer.

Dropper.

Manual instructions.

【SPECIFICATION OF OF NEUTRALIZING ANTIBODY TEST】

1Test/Kit, 20Tests/Kit, 25Tests/Kit, 50Tests /Kit, 100Tests/Kit

【INTENDED USE OF NEUTRALIZING ANTIBODY】

This product is used for qualitative detection of neutralizing antibodies of SARS-COV-2 in human serum, plasma, whole blood. It is suitable for the auxiliary diagnosis of antibody production in persons who have been vaccinated with Novel Coronavirus (SARS-CoV-2) vaccine. This reagent only provides preliminary analytical test results for clinical reference only, and cannot be used as a basis for the production of immune antibodies alone.

【SUMMARY OF NEUTRALIZING ANTIBODY】

Coronavirus (CoV) belongs to the genus Nestovirus, Coronaviridae, and it is divided into three genera:α, β and γ. The genus α and β are only pathogenic to mammals.The genus γ mainly causes bird infections. CoV is mainly transmitted through direct contact with secretions or through aerosols and droplets. There is also evidence that it can be transmitted through the fecal-oral route.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or 2019-nCoV) is an enveloped non-segmented positive-sense RNA virus. It is the cause of coronavirus disease 2019 (COVID-19), which is contagious in humans.

SARS-CoV-2 has several structural proteins including spike (S), envelope (E), membrane (M) and nucleocapsid (N). The spike protein (S) contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor, angiotensin converting enzyme-2 (ACE2). It is found that the RBD of the SARS-CoV-2 S protein strongly interacts with the human ACE2 receptor leading to endocytosis into the host cells of the deep lung and viral replication.

Infection with the SARS-CoV-2 initiates an immune response, which includes the production of antibodies in the blood. The secreted antibodies provide protection against future infections from viruses, because they remain in the circulatory system for months to years after infection and will bind quickly and strongly to the pathogen to block cellular infiltration and replication. These antibodies are named neutralizing antibodies.

【OPERATION PROCEDURE OF OF NEUTRALIZING ANTIBODY RAPID TEST】

Step 1: Remove the sample to be tested and the reagent required from the storage condition and balance it to room temperature (15 ~ 30℃);

Step 2: To prepare for the test, tear the aluminum foil bag, .and take out test cassette, put it on the horizontal table;

Step 3: Label the sample number on the test cassette;

Step 4: Before the test, thoroughly mix the sample (serum, plasma or whole blood sample) and add 2 or 3 drops of the sample into the sample well on the test cassette;

• Serum or Plasma Specimens:

Use the Dropper to transfer 2 drops of serum/plasma (approximately 50µL) into the specimen well of the test cassette, then add 1 drop of buffer. And start the timer.

• Whole Blood (Venipuncture/Fingerstick) Specimens:

Use the Dropper to transfer 3 drops of whole blood (approximately 75µL) into the specimen well of the test cassette, then add 1 drop of buffer. And start the timer.

Step 5: Timing, 10-15 minutes to determine the test result.

Do not interpret the result after 15 minutes.