Active Member
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Address: No.86, Gaoxin Rd., High-Tech Development Zone, Xi’an, 710065, China
Contact name:Sara Zhao
Evergreen Biotech Inc |
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sara@extractspowder.com
broad-spectrum antibiotics Chloramphenicol Cas: 56-75-7
Chloramphenicol is a broad spectrum antibiotic against gram-positive and gram-negative bacteria. It is often used for bacterial selection in molecular biology and as a selection agent for transformed cells containing chloramphenicol resistance genes. Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.
Application:
It is used for the treatment of serious infections when the microorganism is resistant to less toxic antibiotics and also when its ability to penetrate to the site of the infection is superior to less toxic alternative antibiotics.
It is used only when safer drugs are contraindicated; pregnancy, lactation, or known hypersensitivity to this drug also prohibits its use.
| Test | Specification |
| Appearance | A white, greyish-white or yellowish-white, fine, |
| crystalline powder or fine crystals, needles or elongated plates | |
| Identification | |
| A: Melting point: 149 ~ 153 | |
| B: The infrared absorption spectrum obtained with sample | |
| corresponds to that obtained with Chloramphenicol CRS. | |
| Acidity or alkalinity | ≤0.1ml |
| Specific optical rotation | +18.5°~+20.5° |
| Related substances | Single impurity≤0.5% |
| Chloride | ≤100 ppm |
| Loss on drying | ≤0.5% |
| Sulphated ash | ≤0.1% |
| Assay | 98.0% ~ 102.0% (on the dried basis) |
| Residual solvent | Methanol≤3000ppm |
