• Usually, the material must be weighed in the clean area to avoid changing its original purity. According to the biological activity of the material, its weighing should be completed in a completely independent area (independent fume hood, air flow form and dust capture). Grade D, grade C or grade A shall be selected according to the microbial contamination level of starting materials (e.g. < 100 CFU / g) or the requirements of process risk assessment.

• Weighing equipment

  The weighing room distributes raw and auxiliary materials according to the process prescription. Only one kind of material is allowed to be weighed and prepared at the same time. In the weighing process, a large amount of dust will be produced, so pollution and cross pollution should be avoided to the greatest extent.

  It is recommended to operate in an area equipped with a dust removal system to minimize the operator's exposure to the product.

  At present, there is a relatively new dust removal method, which adopts local dust removal facilities. The system is equipped with primary, intermediate and high-efficiency filters, and operates in self circulation mode with vertical downward air outlet. This method can effectively control the dust from flying; all dust is collected on the primary effect filter bag, and the unified product is replaced regularly or according to the differential pressure indication, and different active ingredients are replaced Different filter bags can not only avoid cross pollution but also air pollution. For highly sensitized materials, it may be required to operate in a separate cabinet with half body or glove holes.

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