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best selling products betulinic acid powder 472-15-1 in bulk
product details
Product name:Betula alba L bark extract
Active ingredient:Betulinic acid
Used Part:bark
Specification: 98%
CAS NO. : 472-15-1
Appearance:White Powder
Flavor: Characteristic taste
Particle Size:80% pass through 80 mesh sieve
Test mothed: HPLC
Molecular formula:C30H48O3
Molecular Weight : 456.71
Extract Solvent: Ethanol & Water
Solubility: Not Soluble in water, lightly soluble in ethanol
Usage: Pharmaceuticals, healthcares,and cosmetics
Product Description
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an
anticancer agent, by inhibition of topoisomerase.It is found in the bark of several species of plants, principally the white birch (Betula pubescens) from which it gets its name, but also the ber
tree (Ziziphus mauritiana), selfheal (Prunella vulgaris), the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas, a member of the persimmon family, Tetracera boiviniana, the jambul (Syzygium formosanum),flowering quince (Chaenomeles sinensis), rosemary, and Pulsatilla chinensis
Product Analysis
| Item | Specification | Result | Method |
| BasicProduct Information | |||
| Product name | 472-15-1 | ||
| Part of the Plant | bark | Conform | / |
| Country of Origin | China | Conform | / |
| Organoleptic Data | |||
| Appearance | Fine powder | Conform | NLS-QCS-1008 |
| Color | white powder | Conform | GB/T 5492-2008 |
| Odor& Taste | Characteristic | Conform | GB/T 5492-2008 |
| Process Data | |||
| Solvent(s) Used | Water and ethyl alcohol | Conform | / |
| Extract ration | / | Conform | |
| Content | Paeoniflorin≥98% | 98.18 | |
| Drying Method | Spray drying | Conform | / |
| Excipient | Maltodextrin | Conform | / |
| Physical Characteristics | |||
| Particle Size (80 mesh) | 98.0%pass 80mesh | Conform | GB/T 5507-2008 |
| Moisture | <5.0% | 2.8% | GB/T 14769-1993 |
| Ash Content | <4.0% | 1.4% | AOAC 942.05, 18th |
| Solvent Residue | Eur. Pharm | Conform | NLS-QCS-1007 |
| Heavy Metals | |||
| Total Heavy Metals | <10 ppm | Conform | USP <231>, method II |
| Arsenic | <1.0 ppm | Conform | AOAC 986.15, 18th |
| Lead | <1.0 ppm | Conform | AOAC 986.15, 18th |
| Mercury | <0.5 ppm | Conform | AOAC 971.21, 18th |
| Pesticide Residue | |||
| 666 | <0.2ppm | Conform | GB/T5009.19-1996 |
| DDT | <0.2ppm | Conform | GB/T5009.19-1996 |
| Microbiology | |||
| Total Plate Count | <1,000cfu/g | 17cfu/g | AOAC 990.12, 18th |
| Total Yeast & Mold | <100cfu/g | 3cfu/g | FDA (BAM) Chapter 18, 8th Ed. |
| E. Coli | Negative | Negative | AOAC 997.11, 18th |
| Salmonella | Negative | Negative | FDA (BAM) Chapter 5, 8th Ed. |
Product Function
1.Anti-tumor, anti-HIV agent which induces apoptosis via activation of caspases.
2.The potential of betulinic acid was tested using three human melanoma cell lines, MEL-1, -2, -3, and -4. The growth of all of the cell lines was inhibited significantly by treatment with betulinic acid.
3.Betulinic acid seems to work by inducing (programmed cell death) in cancer cells
4.Betulinic acid has also been found to retard the progression of HIV 1 infection, which eventually leads to , by preventing the formation of syncytia (cellular aggregates).
