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Address: Qiaokou District, Wuhan, China
Contact name:Gayle
Wuhan Shuiyixing Pharmaceutical Chemical Co., Ltd. |
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Naturally Occurring Steroid Hormone Estriol For the Treatment of Menopausal Hormones
| Product name | Estriol |
| CAS No. | 50-27-1 |
| MF | C18H24O3 |
| MW | 288.38 |
| Melting point | 280-282 °C(lit.) |
| Boiling point | 370.61°C (rough estimate) |
| Density | 1.27 |
| storage temp | -20°C Freezer |
Estriol (E3) is an estrogenic drug and a naturally occurring steroid hormone used in the treatment of menopausal hormones. It can also be used in veterinary medicine as Incurin for the treatment of urinary incontinence due to estrogen deficiency in dogs. The drug is applied to the skin by oral administration in the form of a tablet, a cream, as a cream or pessary, which is applied in the vagina and by injection into the muscle.
Estradiol is well tolerated and produces relatively few adverse reactions. Side effects may include breast tenderness, vaginal discomfort and secretions, and endometrial hyperplasia. Estriol is a naturally occurring and bio-homologous estrogen, or an agonist estrogen receptor, an endogenous estradiol of the biological target estrogen or the like. This is an atypical and relatively weak estrogen, with much lower potency than estradiol.
Estriol was first discovered in 1930 and was soon introduced for medical use. Estriol esters such as estriol succinate can also be used. Although it is used at a lower rate than other estrogens such as estradiol and conjugated estrogens, estriol is widely used in medical applications in Europe and elsewhere in the world.
Medical use
Estriol is used in menopausal hormone therapy to treat menopausal symptoms such as hot flashes, vulvovaginal atrophy and difficulty in intercourse (difficulty or sexual intercourse). The benefits of estriol on bone mineral density and prevention of osteoporosis have been inconsistent and unclear. Estriol has been found to reduce the risk of urinary tract infections and other genitourinary symptoms. The combination of estriol and lactobacilli has been marketed as a dual estrogen and probiotic for the treatment of vaginal atrophy and urinary tract infections.
Side effect
Estradiol is well tolerated and produces relatively few adverse reactions. Breast tenderness can sometimes be a side effect of estriol. Local reactions with vaginal estriol, such as discomfort (irritation, burning, itching) and secretions, may occur. Estriol may produce endometrial hyperplasia similar to estradiol and other estrogens, so women with intact uterus should be combined with progesterone to prevent this risk. However, it appears that the typical clinical dose of vaginal estriol is not associated with an important risk of endometrial hyperplasia or hyperplasia. Similarly, in the case of vaginal estriol, it may not be necessary to use it in combination with progesterone. Some studies have shown that oral estriol may also be the case. However, the dose and frequency of administration and the amount of meal may be the determining factor for whether estriol produces endometrial hyperplasia.
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Estriol Powder:
