Wuhan Shuiyixing Pharmaceutical Chemical Co., Ltd. |
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Growth Hormon Releasing Peptide-6 GHRP-6 Powder For improve Injury Healing And Skin
Quick Detail:
Product name | GHRP-6 |
CAS No. | 87616-84-0 |
MF | C46H56N12O6 |
MW | 873.01 |
storage temp | −20°C |
Uses | Polypeptide Hormones |
Description:
GHRP-6 is most generally used for the same purposes that GH might
be used, but may be chosen where a cost advantage exists favoring
GHRP-6, GH is not available, or the individual prefers the idea of
stimulating his own GH production to injecting GH.
These purposes can include increased fat loss, improved muscle gain
when used in combination with anabolic steroids, cosmetic
improvement of the skin, and improved healing from injury.
There is no need to cycle GHRP use, and so therefore GHRP-6 may be
used whenever it is thought to be useful for any of the above
reasons. However, when usage is ongoing instead of short-term
amplification of a steroid cycle or fat-loss program, I recommend
limiting dosage to the minimum end of the suggested dosage range.
Increased effect from combining GHRP-6 with a GHRH:
While GHRP-6 is capable of inducing large increases in GH
production when used alone, a given dose will show markedly more
effect what a GHRH (growth hormone releasing hormone) peptide is
taken at the same time. Alternately, when combining a GHRH with
GHRP-6, only about half or a third as much GHRP-6 is needed to
obtain the same increase in GH production.
For this reason, it’s a common choice to combine a GHRH with a
GHRP, but excellent results are often obtained without doing so. A
preferred choice of GHRH is Mod GRF 1-29 (also known as CJC-1295
without DAC.)
How to use GHRP-6?
GHRP-6 is most commonly provided in small vials of 5 mg, which
should be stored under refrigeration. (It is acceptable however for them to be mailed unrefrigerated.)
The vial is diluted with a convenient volume of sterile or
bacteriostatic water. For example, the vial might be diluted with
2.5 mL of water, yielding a solution of 2 mg/mL (2000 mcg/mL.)
After the water addition, the vial again will be stored under
refrigeration.
When dosing, an appropriate volume will be drawn from the vial with
(typically) an insulin syringe, according to the desired dose and
the concentration of the preparation. In the above example, a 100
mcg dose would require only 0.05 mL, or “5 IU” as marked on an
insulin syringe. A 300 mcg would require 0.15 mL, or “15 IU” as
marked on an insulin syringe.
Injection may be subcutaneous, intramuscular, or intravenous
according to personal preference.
Dosing will ordinarily be at least twice per day and preferably
3x/day for best effect, taken at least 30-60 minutes before a meal
and at a time of non-elevated blood sugar (in other words, after
blood sugar has had time to fall since the most recent meal.) The
amount taken generally will be from 50-300 mcg at a time. When
using a GHRH along with GHRP-6, dosing should be reduced to 50-100
mcg at a time.
For increase in GH levels, higher doses within the suggested range
definitely increase effect. With regard to healing benefit, for
example for tendonitis, the low end of the range is often entirely
sufficient and noticeably greater effect is not necessarily seen
with increased dose.
While there is no sharp cut-off between a solution of GHRP-6 still
being good and having lost potency with time, as a general
guideline, a vial should be used within a month of having been
reconstituted. Past this, I would discard the vial and start a new
one.
Pharmacological class: Mimetic of ghrelin
GHRP-6 and all GHRP’s are mimetics of ghrelin, a hormone produced
by cells of the stomach in response to a fasted condition,
including brief fasts. Ghrelin and ghrelin mimetics work by
activating the ghrelin receptor, also called the growth hormone
secretagogue receptor (GHS-R1a). Elevated ghrelin levels act
towards increasing GH levels by stimulation of ghrelin receptors in
the pituitary.
Injection of GHRP-6 or any GHRP stimulates GH release in
essentially the same way as fasting-induced elevation of ghrelin
levels. The effect can be markedly greater, however.
Supraphysiological levels of GH are easily achieved with proper
dosing of any GHRP.
Other activities of ghrelin, and potentially of GHRP-6
Ghrelin has many activities in the body besides stimulating GH
release. It stimulates appetite, is cardioprotective, can help
protect cells against oxidative damage, can reduce inflammation and
promote healing, and can promote fat-burning in muscle. There is
also some effect on increase in cortisol production via increase in
ACTH, and increase in prolactin. However, where the activity of
ghrelin is comparable to that which ordinarily occurs during
fasting, effects on cortisol and prolactin likewise are comparably
only to that experienced while fasting.
Ghrelin itself so far as I know has not been used as a
performance-enhancing drug. In contrast, experience with GHRP’s is
quite extensive. GHRP-6 in particular has in many cases been
effective in treating tendonitis, which may well be due to its
activity at the ghrelin receptor.
Broadly speaking, it’s long been a widespread view that fasting can
in many instances provide healthful effects beyond simple fat loss.
It’s speculative to say that increased ghrelin levels must be a
major cause of such effect (if granting the effect), but it’s
entirely consistent with the scientific literature that such
elevation of ghrelin levels may have health benefits.
Appropriate-dosed and cycled GHRP use may at least partially
provide such benefits, particularly with regard to
anti-inflammatory and healing effect.
There are indications in the literature of ghrelin acting to
promote fat-storage, but this appears to be tissue-specific, for
example in the liver. In bodybuilding, by no means has any such
effect been apparent with GHRP-6. Instead, GHRP-6 has been
effective as a cutting drug, provided that food intake is
controlled.
Because some GHRP’s are equally effective as others in increasing
GH but differ in effect on hunger or ACTH stimulation, it seems
likely that there may be differences in ghrelin receptors between
different tissues, or differences in function (for example with
cofactors.) This is the most likely explanation for GHRP-6 being
effective in stimulating hunger and helping heal tendinitis, while
GHRP-2 stimulates hunger less and may have less value for healing.
Factors decreasing efficacy of GHRP-6:
For increasing GH levels, GHRP-6 is less effective in the presence
of high blood glucose levels or high somatostatin levels, which
result from high IGF-1 levels. For this reason, for best effect
GHRP-6 should be taken while blood sugar is relatively low, for
example about 30-60 minutes before a meal. GHRP-6 will have reduced
effect if GH is being taken by injection, because GH increases
IGF-1. Where GH use is limited to no more than about 14 IU per
week, simultaneous GHRP-6 use probably still will increase GH
somewhat further, but if GH use is greater than this then likely
GHRP-6 injections will do little to nothing towards increasing GH
levels any further.
Low thyroid levels also decrease efficacy of GHRP-6, and modestly
increased thyroid levels, such as with 50-200 mcg/day of T4, or
12.5-50 mcg/day of T3, may improve efficacy. (If T3 is used, dosage
should be divided into three doses per day.)
Dosage:
GHRP-6 is a water based injectable that you will have to mix with
bac water, and store. Remember, it is important to store GHRP-6
correctly after mixing it - in the fridge. It should be good for up
to 3-4 weeks, so only mix what you plan on using during that time
frame.
After you carefully mix it, this compound is typically injected
subcutan eously with a slin pin. For best results, it must be taken
daily, and users will typically do several injections per day in
order to space it out. Interestingly, GHRP-6 works best if you take
it when blood sugar levels are low, and you should not eat anything
for an hour after using it.
If used solo, users will run 100-400 micrograms (mcg) per
injection, and if stacked with another GH hormone, dosages can be
cut in half.
Conclusion
GHRP-6 can effectively provide substantial increases in GH
production. It’s typically taken 2-3 times per day by injection at
times when blood sugar is not elevated. Cost is generally moderate.
The only common potential adverse side effect is increased hunger.
Common alternates include GHRP-2, hexarelin, ipamorelin, or GH
itself. GHRP-6 also may provide benefits which GH does not, via its
action at the ghrelin receptor in various tissues of the body.
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