Active Member
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Address: 12F,Guting Building,Hefeng Creative Square,No.495 Jiangdong North Road,Ningbo,Zhejiang, China
Contact name:Jerry Meng
Orient New Life Medical Co.,Ltd. |
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Recombinant COVID-19 Mouse Monoclonal Antibody
Background
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
| Name | COVID-19 Mouse Monoclonal Antibody
| Application | Invitro research and manufacture use; membrane assay, ELISA assay, |
| Perseverative | 1 0.02% sodium azide.
| Buffer: | 1X PBS buffer |
| Storage: | Short-term: refrigerated at 2-8 ºC; long term: frozen at or below -20 ºC. | Concentration | 1.0 mg/mL |
| Expiration Date: | 14 days refrigerated at -2-8ºC and two years frozen at -20 ºC or below from production date. To be evaluated independently | Feature | High Sensitivity and Specificity |
Specification Data
| Description: | Monoclonal Antibody to Acetaminophene | |
| Clone: | SARS-CoV-2 (2019-nCoV) Spike RBD Protein | |
| Source: | Rabbit IgG | |
| Immunogen: |
HCoV-HKU1 (isolate N1) Spike S1 Protein HCoV-HKU1 (isolate N5) Spike S1 Protein HCoV-NL63 Spike S1 Protein | |
| Formulation: |
0.22 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80 | |
| Purification: | DEAE chromatography | |
| Concentration: | 1.0 mg/mL (OD280 nm, E0.1% = 1.40) | |
| Affinity Constant: | Not determined | |
| Buffer: | 0.015M potassium phosphate buffer, 0.85% NaCl, 0.05% NaN3 pH=7.2 | |
| Pairing Assays: | N/A | |
| Purity: | >95% by HPLC and SDS-PAGE | |
| Application: |
Enzyme immunoassay/ Lateral flow (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.) | |
| Storage: | 2-8o C for 1 year. Store at -200 C for long term. | |
FAQ
1. Q:Are you a factory or trading company?
A: We are a factory, we have rich experience for manufacturing Medical Device more than 10 years.
2.Q:Where is your factory located? How can i visit there?
A: Our factory is located in Jiaxing city, Zhejiang Province, China.
It is about more than 1 hours from Shanghai.
2. 3.Q:Can you make samples?
A: Yes, we can make samples for you.
4.Q:How does your factory do as quality control?
A: Quality is the lift of our factory. We have inspector in
different post, and there are three inspectors before packing to
get best quality products.
5.Q: How is your post market service ?
A: If any damaged rings in the course of carriage, with the
checking it's our mistake, we will take full responsibility to compensate the customers.
6.Q:Can you do OEM for us?
A: Certainly. We also can build the moulding for our new customer.
7.Q:Does the price include freight?
A:No, please choose the express service provider or negotiate with
us.
