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PDK1 Rabbit Polyclonal Antibody Highly Specificity
Cat.No. BT-AP00052 Size: 100ul/50ul/20ul Datasheet Request
Product Information
Clonallity: Polyclonal
Applications: WB,IHC-p,ELISA
Source: Rabbit
Immunogen: Synthesized peptide derived from human PDK1 around the non-phosphorylation site of Y9
Protein Name: 3-phosphoinositide-dependent protein kinase 1
Species reactivity: human, mouse, rat, monkey
Observed band: 60 kDa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Synonyms:
PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1
Storage:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C.
Background
PDK1(pyruvate dehydrogenase kinase isoform 1) is also named as PDHK1 and belongs to the PDK/BCKDK protein kinase family. It inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. Starvation increases islet PDK activity. PDK1 has 2 isoforms with the MW of 49 and 52 kD, and a 28aa-transit-peptide in the N-terminal can be removed in the mature form. This antibody is speicfic to PDK1.
