Keypath p16 Immunoassay Test Kit(ICC) is used for
immunohistochemical staining on the basis of routine staining
(such asHE staining), and provides diagnostic auxiliary information
for doctors.
Based on the principle of specific binding between immunological
antigen and antibody, the antibody is combined with enzyme-labeled
chromogenic system to form a complex, and enzyme substrate
(chromogenic agent) is added to make it chromogenic to locate and
characterize the antigen to be detected. The location of cell
staining is nucleus/cytoplasm.
P16 is one of the cell cycle regulatory proteins, also known as
"mitosis inhibitor". Its role is to competitively bind CDK4/6 with
cyclin D, and stop
the process of cells from G1 to S, thus negatively regulating
mitosis. In tumor cells, gene mutation or deletion often leads to
the increase of p16
expression, but the cell cycle can not be regulated. This antibody
is mainly used in tumor research.