Wuhan Shuiyixing Pharmaceutical Chemical Co., Ltd. |
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99% Purity Health Supplement Dutasteride Avodart For Treat Hair Loss CAS 164656-23-9
Product name | Dutasteride (Avodart) |
CAS No. | 164656-23-9 |
MF | C27H30F6N2O2 |
MW | 528.53 |
EINECS | 638-758-5 |
Melting point | 242-250°C |
storage temp | -20°C Freezer |
Appearance | White or almost white crystalline powder |
1. Dutasteride useful for the symptoms of benign prostatic
hyperplasia (BPH); colloquially known as an "enlarged prostate".
2. In those who are being regularly screened 5-alpha-reductase
inhibitor (finasteride and dutasteride) reduce the overall risk of
being diagnosed with prostate cancer however there is insufficient
data to determine if they have an effect on the risk of death and
may increase the chance of more serious cases.
3. This class of medications increases rates of erectile
dysfunction (with between 5% and 9% developing problems after
starting their use). This is linked to lower quality of life and
can cause stress in relationships. There is also an association
with lowered sexual desire. It has been reported that these adverse
sexual side effects may persist even after discontinuation of the
drug.
4. The FDA has added a warning to dutasteride about an increased
risk of high-grade prostate cancer. While the potential for
positive, negative or neutral changes to the potential risk of
developing prostate cancer with dutasteride has not been
established, evidence has suggested it may temporarily reduce the
growth and prevalence of benign prostate tumors, but could also
mask the early detection of prostate cancer.
5. The primary area for concern is for patients who may develop
prostate cancer whilst taking dutasteride for benign prostatic
hyperplasia, which in turn could delay diagnosis and early
treatment of the prostate cancer, thereby potentially increasing
the risk of these patients developing high-grade prostate cancer.
Applications :
1. Dutasteride is marketed pharmaceutically as Avodart, Avidart,
Avolve, Duagen, Dutas, Dutagen, Duprost. For unknown reasons, early
clinical trials for dutasteride were abruptly ceased in 2002, then
continued later.
2. Dutasteride, at 2.5mgs/day is roughly 1.5x more effective than
Finasteride at 5mgs/day, at treating hair loss (both halting it as
well as regrowing it). In addition, Dutasteride can be used
successfully at that same dose to treat prostate enlargement, and a
lesser known effect of Dutasteride (again, at that same dose) use
is to treat Acne caused by an overabundance of androgens in the
body.
3. For the steroid using athlete suffering from DHT-related side
effects, Dutasteride may be the answer. Hairloss, Acne, and
prostate growth can all (potentially) be completely halted with the
use of this product. Unfortunately, DHT is not all bad, and you
potentially lose some muscle hardness (an amorphous quality if ever
there is one), and even some of the other qualities we like from
our androgen use.
4. since this only prevents the 5a-reduction of the androgens
subject to that conversion into a dihydro form of them…it will
likely do nothing to stop hairloss or other symptoms caused
entirely by the use of the androgens in the DHT family.
Medical Use :
1. Prostate enlargement
Dutasteride is useful for treating benign prostatic hyperplasia
(BPH); colloquially known as an "enlarged prostate".
2. Prostate cancer
In those who are being regularly screened, 5α-reductase inhibitors
such as finasteride and dutasteride reduce the overall risk of
being diagnosed with prostate cancer; however, there is
insufficient data to determine if they have an effect on the risk
of death and may increase the chance of more serious cases.
3. Pattern hair loss
Dutasteride is approved for the treatment of male androgenetic
alopecia in South Korea at a dosage of 0.5 mg per day. It has been
found in several studies to improve hair growth in men more rapidly
and to a greater extent than 2.5 mg/day finasteride.Dutasteride has
also been used off-label in the treatment of female pattern hair
loss.
How Dose Dutasteride Work :
Dutasteride belongs to a class of drugs called 5α-reductase
inhibitors, which block the action of the 5α-reductase enzymes that
convert testosterone into DHT. It is an irreversible inhibitor of
all three isoforms of 5α-reductase, types I, II, and III.This is in
contrast to finasteride, which is similarly an irreversible
inhibitor of 5α-reductase but only inhibits the type II and III
isoenzymes.As a result of this difference, dutasteride is able to
achieve a reduction in circulating DHT levels of as much as 95%,
whereas finasteride is only able to achieve a reduction of 70%. In
spite of the differential reduction in circulating DHT levels, the
two drugs decrease levels of DHT to a similar extent (approximately
85 to 90%) in the prostate gland,where the type II isoform of
5α-reductase predominates.
In addition to DHT, dutasteride prevents the 5α-reductase-mediated
formation of neurosteroids such as allopregnanolone and THDOC, and
3α-androstanediol (see also neurosteroidogenesis inhibitor).These
neurosteroids are potent positive allosteric modulators of the
GABAA receptor and have been found to possess antidepressant,
anxiolytic, and pro-sexual effects in animal research. For this
reason, prevention of neurosteroid formation may be responsible for
the sexual dysfunction and depression that has been associated with
5α-reductase inhibitors like dutasteride.
Do Not Use Dutasteride if :
1. you are allergic to any ingredient in dutasteride or to another
5 alpha-reductase inhibitor (eg, finasteride)
2. the patient is a woman who is pregnant or may become pregnant
3. the patient is a child
Side Effects :
More common side effects
trouble getting or keeping an erection (may continue after stopping
dutasteride)
decrease in sex drive (may continue after stopping dutasteride)
ejaculation problems (may continue after stopping dutasteride)
enlarged or painful breasts. If you notice breast lumps or nipple
discharge, talk to your doctor.
If these effects are mild, they may disappear within a few days or
a couple of weeks. If they’re more severe or don’t disappear, talk
to your doctor or pharmacist.
Serious side effects allergic reactions.
Examples include:
swelling of your face, tongue, or throat
peeling skin
prostate cancer. Symptoms may include:
increased prostate-specific antigen (PSA) concentrations
increased urination frequency
difficulty starting urination
weak urine flow, painful/burning urination. difficulty in having or
maintaining an erection
painful ejaculation, blood in the urine or semen
frequent pain or stiffness in the lower back, hips, or upper thighs
Dose :
The recommended dose of Avodart is 1 capsule (0.5 mg) taken once
daily. Avodart may interact with conivaptan, imatinib, isoniazid,
antibiotics, antifungal medications, antidepressants, heart or
blood pressure medications, or HIV/AIDS medicine. Tell your doctor
all medications you use. Avodart is not usually used in women.
Therefore, it is unlikely to be used during pregnancy or
breastfeeding.
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