Highly Specific Mouse Source ING2 Rabbit Protein Monoclonal Antibody

Highly specific ING2 Rabbit Monoclonal Antibody

Cat.No. BT-MCA0422  Size: 20ul/50ul/100ul Datasheet Request

Product Information

Clonallity: Monoclonal

Applications: WB, ELISA

Source: mouse

Isotype: IgG

Protein Name: ING2

Immunogen: ING2 fusion protein

Calculated molecular weight:​ 33 kDa

Synonyms: ING1L, ING1Lp, ING2, Inhibitor of growth protein 2, p32, p33ING2

Species specificity: human, mouse, rat

Recommended Dilution:

Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Store at 4°C for a month, for one year store at -20°C. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-20°C. Avoid repeated freeze/thaw cycles.

Background

ING2, also named as ING1L, belongs to the ING family and contains a PHD-type zinc finger. It is induced by the DNA-damaging agents etoposide and neocarzinostatin. As a candidate tumor suppressor, ING2 seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. It is a component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. Recent finding reported that ING2 regulates muscle differentiation by regulating chormatin remodeling program.