ITEMS STANDARD RESULTS
Characteristics White or almost white crystalline powder Almost
white crystalline powder
Melting point 152~156 155.0~155.5
Specific optical rotation -16° -19° -17.4°
The retention time of the major peak in the chromatogram of the
preparation corresponds to that in the chromatogram of the standard
as obtained in the assay
UV absorption Max. at 266 nm Conforms
IR spectra is consistent with CRS Conforms
PH 4.5~6.5 5.2
Chlorides ≤ 0.02% 0.02%
Fluorides ≥ 4.8% 4.80%
Related substances Individual impurity ≤ 0.5% 0.50%
Total impurities ≤ 2.0% 0.90%
Residue on ignition ≤ 0.1% 0.07%
Water ≤ 0.5% 0.06%
Heavy metals ≤ 20ppm
Product name: Dehydroepiandrosterone
CAS Registry Number: 53-43-0
Appearance: White powder
Dehydroepiandrosterone (DHEA) is a multifunctional steroid that has
been implicated in a broad range of biological effects in humans
and other mammals. Together with its sulfate ester (DHEAS), it is
the most abundant steroid in humans. DHEA is produced by adrenal
glands, but also sythesized de novo in the brain.It acts on the
androgen receptor both directly and through its metabolites, which
include androstenediol and androstendione, which can undergo
further conversion to produce the androgen testosterone and the
estrogens estrone and estradiol. DHEA is also a potent sigma-1
agonist. It is considered a neurosteroid DHEA is essential to
sustain life, and there are numerous health benefits to having
healthy levels of natural DHEA. Dr. Arthur Schwartz of the Temple
University School of Medicine says that "DHEA appears to block the
growth of carcinogens".Studies have shown that DHEA is useful in
patients with systemic lupus erythematosus. An application of the
evidence was discussed by the U.S. Food and Drug Administration in
2001 and is available online. This review also shows that
cholesterol and other serum lipids decrease with the use of DHEA
(mainly a decrease in HDL-C and triglycerides can be expected in
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