hydroxypropyl beta cyclodextrin synthetic drugs 128446-35-5
CAS No.: 128446-35-5
· Other Names: 2-HP-BETA-CD,2hpbcd
· MF: (C6H10O5)7.(C3H6O)n n=1-21
· Place of Origin: Shandong, China (Mainland)
· Type: Auxiliaries and Other Medicinal Chemicals, Pharmaceutical intermediates
· Grade Standard: Cosmetic Grade, Food Grade, Medicine Grade, pharmaceutical grade
· Brand Name: Zhiyuan
· Purity: >99%
· Appearance:white,powder,sweet,inodorous,nontoxic
· Quality standard: EP8.0, USP38, CP2015, Enterprise standard
· Shelf life: 24 months
· molecular weight: 1424
· Sample: free of charge
· Standard: USP38,EP8.0,CP2015
· MOQ: 1KG
· Analysis: All detected by ourselves
· Workshop: 100,000 clean GMP room
· Technical Service: Approved
Packaging & Delivery
Packaging Details:Outer:10kg/drum; 20kg/drum Inner: plastic bag
Delivery Detail:within 1-2 days when recieve payment or L/C
Specifications
Specifications
1.Professional Manufacturer
2.It can get rid of smell; enhance stability.
3.Quality standard: USP,CP,EP,Eenterprise stand
Appearance: White Powder, sweet,odorless,non-toxic
Style: 10kg/drum, 20kg/drum
Quality standard: USP, CP, EP,Eenterprise standard
Durability: 36 months
Specification :
ITEMS | SPECIFICATION(USP38) | RESULTS |
Appearance | white powder, insipid, innocent | Qualify |
Assay | ≥98％ | 99.5% |
Degree of Substitution | 2.8-10.5 | 5.5 |
Clarity of solution | 50%(w/v) water solution is clear | clear |
Identification(IR) | same absorption bands with USP Hydroxypropyl Betadex RS | Qualify |
Loss on Drying | ≤10％ | 4.5% |
Conductivity | 10%(w/v) water solution ≤200µS/cm | 70 |
Propylene oxide | ≤1ppm | ＜0.18ppm |
Propylene glycol | ≤2.5％ | 0.05% |
Sum of Other Impurities | ≤1％ | 0.51% |
Betadex | ≤1.5% | 0.39% |
Residue on Ignition | ≤0.2％ | 0.09% |
Heavy Metal | ≤20ppm | ＜10ppm |
chloride | ≤0.05% | ＜0.05% |
Bacterial endotoxins | ≤25EU/g | <20EU/g |
TAMC(cfu/g) | ≤1000 | 80 |
TYMC(cfu/g) | ≤100 | 30 |
Salmonella/E. Coli (cfu/g) | Absent | Absent |
Storage: at room temperature, in tightly closed container.
(1). In medicine field
1.2-Hydroxypropyl Beta Cyclodextrin can increase the solubility of
the medicine and biological availability, also add up the good
effect and decrease the dose.
2.Meanwhile, it control or adjust the reactive speed, lower the
drug toxicity and enhance the stability of drugs.
3.Moreover, 2-HP Beta CD is for oral solution with the highest
safety.
(2).In food field
1.2-Hydroxypropyl beta cyclodextrin can prevent evaporation of volatile substances, maintaining the
stability of its nutrition, get rid of the terrible smell and can
significantly enhance the effects of emulsification with the
combined use of food emulsifiers.
2.2-HP Beta CD can also make food preservative release slowly,
raise the effect of anti-corrosion and extend the shelf life of
food.
(3)In the field of cosmetic
1. 2-Hydroxypropyl Beta Cyclodextrin is used as stabilizers,
emulsifiers, deodorant in cosmetic.
2. 2-Hydroxypropyl Beta Cyclodextrin can decrease the
stimulating effect on the skin produced by organic composition of
cosmetic.
3. 2-Hydroxypropyl Beta Cyclodextrin can prevent nutrient
ingredient evaporating and oxidating, increase water-soluble of
spices and essence, keep fragrance's sustained and release lasting.
Use of 2-hydroxypropyl-beta-cyclodextrin as a solubilizing and
stabilizing excipient for protein drugs.
Abstract
A chemically modified, amorphous beta-cyclodextrin, namely,
2-hydroxypropyl-beta-cyclodextrin (HPCD), was examined as a
solubilizing and stabilizing agent for protein drugs. The aqueous
solubility of ovine growth hormone at pH 7.4 was increased through
the use of HPCD. This effect was manifested by higher UV
transparency at 600 nm. Interleukin-2 (IL-2) is rendered insoluble
upon lyophilization in the absence of stabilizers. Use of aqueous
HPCD provides a clear solution, as indicated by fluorometric light
scattering, and inhibits aggregate formation, as shown by
ultracentrifugation and Western blot analyses. In addition, there
were no major conformational changes of IL-2 in HPCD formulation as
indicated by fourth-derivative ultraviolet spectroscopy. Finally,
IL-2 retained 100% of its biopotency when prepared in HPCD
solutions. Aggregation of insulin was also suppressed by HPCD.
These data, as well as the i.v. safety of HPCD and its
well-characterized chemical composition, suggest that this starch
derivative may be a potentially useful excipient for protein drugs
intended for parenteral use.
Company profile
Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd. is a leading manufacturer and supplier with derivatives of cyclodextrin product and technology portfolio encompassing a wide range of applications.
Now we have the most advanced domestic production lines: Hydroxypropyl beta cyclodextrin, Sulfobutyl ether beta cyclodextrin Sodium, Methy cyclodextrin, Mercapto cyclodextrin, Amino cyclodextrin, Ethanediamine Cyclodextrin,Piroxicam cyclodextrin, cyclodextrin polymers etc. Also synthesis custom designed cyclodextrin derivatives.
we have Ion chromatograph (IC), Capillary electrophoresis (CE), High performance liquid chromatograph (HPLC), Gas chromatograph (GC), Fourier transform infrared spectroscopy (FTIR) and other imported advanced testing equipments. Multiple means of analysis and inspection help us ensure production quality and accelerate new production developing.
We are particularly focusing and elaborating on the niche products and services ignored by the traditional larger suppliers in the market:
l We customize our products routinely to meet customers' unique requirements;
l We specialize in sourcing difficult-to-find chemicals and delivering them to our customers quickly and efficiently;
l We expand our business by identifying and capitalizing on opportunities for novel products and techniques at early stage;
l We maintain cost structure low to accommodate customers' budgets.
We satisfy our customers with the highest quality products, services, technical and commercial supports. Whether you are looking for a hard-to-find product, an existing product with new specifications, or a new form 
of a known material, we can meet your challenges in a reliable, efficient and cost effective manner.
We are poised to meet your next challenge.
We specializing in the production of all kinds of characteristics of cyclodextrin derivatives,sush as below:
Sulfobutyl Ether-β-cyclodextrin Sodium Salt CAS: 182410-00-0
Hydroxypropyl-β-cyclodextrin CAS:128446-35-5
Hydroxypropyl-γ-cyclodextrin CAS:128446-34-4
Methyl Beta Cyclodextrin CAS:128446-36-6
2,6-di-O-Methyl Beta Cyclodextrin CAS: 51166-71-3
Carboxymethyl-β-Cyclodextrin sodium salt CAS: 218269-34-2
Piroxicam Beta Cyclodextrin CAS:96684-39-8
mono-(6-amino-6-deoxy)-β-cyclodextrin CAS:29390-67-8
mono-(6-p-toluenesulfonyl)-β-cyclodextrin CAS:67217-55-4
mono-(6-ethanediamine-6-deoxy)-β-Cyclodextrin CAS:60984-63-6
mono-(6-Mercapto-6-deoxy)-β-Cyclodextrin CAS:81644-55-5
Mono-(6-azido-6-deoxy)-β-Cyclodextrin CAS:98169-85-8
α-cyclodextrins, Alfadex CAS:10016-20-3
γ-cyclodextrin CAS:17465-86-0
β-cyclodextrin, cyclomaltoheptaose CAS: 7585-39-9
mono-(6-(1,6-hexamethylenediamine) CAS:131991-61-2
-6-deoxy)-β-Cyclodextrin
Any related inquiry, pls contact with us.
Sincerely
Terry
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd
Boxing Economic Development Zone,Binzhou city,Shandong,China
Cell : +86 15254382393
Tel : +86 543 2616568
Skype: terrygu0828
E-mail: zyswterrygu@163.com
