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Ropinirole Hydrochloride Pharmaceutical Raw Material for Parkinson's disease

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Ropinirole Hydrochloride Pharmaceutical Raw Material for Parkinson's disease

Country/Region china
City & Province zhuhai guangdong
Categories Adhesives & Sealants

Product Details

Ropinirole Hydrochloride Pharmaceutical Raw Material for Parkinson's disease 

 

 

1. Ropinirole Hydrochloride Quick detail:

Product name

Ropinirole hydrochloride

CAS NO.

91374-20-8

Synonyms

Ropinirole hydrochloride

CategoryPharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
Purity

99% Ropinirole hydrochloride

Appearance

Ropinirole hydrochloride powder

Shelf life2 years for Ropinirole hydrochloride
Usage

Ropinirole hydrochloride was used in the treatment of Parkinson's disease and restless legs syndrome. used in the treatment of Parkinson's disease and restless legs syndrome

StorageRopinirole hydrochloride should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.


 
2. 
Ropinirole Hydrochloride Description:

Ropinirole Hydrochloride
Ropinirole Hydrochloride (trade names Requip, Repreve, Ronirol, Adartrel) is a dopamine agonist of the non-ergoline class of medications. It is used in the treatment of Parkinson's disease and restless legs syndrome (RLS). Ropinirole Hydrochloride is one of three medications approved by the FDA to treat Restless Legs Syndrome (RLS), the other two being Pramipexole Hydrochloride (Mirapex) and gabapentin enacarbil (Horizant). The discovery of the drug's utility in RLS has been used as a successful example of drug repurposing. Ropinirole Hydrochloride is for mainly Parkinson's disease, restless leg syndrome, and extrapyramidal symptoms. It can also reduce the side effects caused by selective serotonin reuptake inhibitors, including Parkinsonism syndrome as well as sexual dysfunction and erectile dysfunction caused by either SSRIs or antipsychotics. 
 
3. 
Ropinirole Hydrochloride Function: 

A- Used in the treatment of Parkinson's disease 
B- Can also be used with levodopa. 
Storage: Stored in cool and dry place, keep away from strong light/heat. 
Shelf Life: 2 years when properly stored.
 
4. 
Ropinirole Hydrochloride Specifications :

Appearance

White crystalline powder

White Crystalline powder

Identification

Infrared Absorption

Conforms

Clarity and color of solution

Clear and nearly colorless

Clear and nearly colorless

PH

3.0~5.5

4.0

Heavy metals

Not more than 0.001%

<0.001%

Organic volatile
(acetone)

Not more than 0.05%

0.03%

Related substances

Individual unknown impurity:NMT0.3%
Total impurities: NMT 1.0%

0.03%
0.08%

Assay

97%~100%

98%

 

Test  Item

Analysis  Specification

Result

Description

White or pale yellow powder

Conform

Identification

IR spectrum of the test sample corresponds to the IR spectrum of reference standard

Positively responds to the test for chlorides.

Conform

Loss On Drying

NMT0.5%

0.26%

Residue on ignition

NMT0.1%.

0.09%

Related substance

Individual known impurity NMT 0.15%

Individual unknown impurity NMT 0.10%

Total impurities NMT 1.0%

0.098%

0.0081%

0.12%

Content of chloride

11.5%~12.5%

11.71%

Heavy metals

NMT 20ppm

Conform

Assay

98.0%~102.0%(calculated on the anhydrous basis)

99.53%

Residual solvents

 

 

Acetone

Not more than 5000ppm

Not detected

Ethyl acetate

Not more than 5000ppm

3690ppm

Ethanol

Not more than 5000ppm

655ppm

Toluene

Not more than 890ppm

Not detected

N,N-Dimethylacetamide

Not more than 1090ppm

Not detected

Conclusion

Qualified

 

 

5. Ropinirole Hydrochloride Product picture:


 

 

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