Hydroxy-PEG7-T-Butyl ester​ Is For PEGyation

Features:

1, Hydroxy-PEG7-T-Butyl ester is Colorless to straw-colored liquid with a mild odor. Sinks and mixes with water.

2, It is Stable, Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

3, PEG is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents.

4, They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior.

5, They may initiate the polymerization of isocyanates and epoxides.

Biologics as therapeutics have gained substantial relevance during the past decades. Many of them are growth factors, interferons, enzymes, or antibodies and essentially contribute to the successful treatment of severe human diseases today. However, biologics routinely suffer from premature degradation by the patient defense system or renal excretion. The most established and best validated drug delivery strategy to overcome these problems is “PEGylation”, the modification of molecules with polyethylene glycol (PEG).