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Solvent Extraction Raw Powder Ethyl Ferulate For Preventing Ultraviolet Light Damage 4046-02-0

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Solvent Extraction Raw Powder Ethyl Ferulate For Preventing Ultraviolet Light Damage 4046-02-0

Country/Region china
City & Province wuhan hubei
Categories Chemical Stocks

Product Details

 

Solvent Extraction Raw Powder Ethyl Ferulate For Preventing Ultraviolet Light Damage 4046-02-0

 

 

Wuhan Lianshangwang Technology Co.,LTD

Contact person:helena liu

coco@yuanchengtech.com

whatsapp:+86 18872220806

 

 

Ethyl Ferulate Details:

 

CAS4046-02-0
Chemical name4-Hydroxy-3-methoxycinnamic acid ethyl ester
M FC12H14O4
M W222.24
StorageStore in an airtight container, protected from light.
Executive standardEnterprise Standard
Main indexAppearance: white crystalline powder
Melting point: 63-65 °C
Loss on drying:≤ 0.10%
Assay(HPLC): ≥98.0%
Packing specification25kg/drum

 

 

Ethyl Ferulate Description:

 

Ethyl Ferulate (4-hydroxy-3-methoxycinnamic acid, FA) is a naturally occurring plant product that has long been studied due to its potential beneficial health properties, including anti-oxidative. anti-inflammatory , neuroprotective and antiproliferative activities. The efficiency of FA as an antioxidant compound has been linked to the stability of its phenoxyl radical due to charge delocalization between the aromatic ring and the double bond in the side chain.

 

In the same direction, the alkyl ester derivative of ferulic acid, ethyl ferulate (ethyl 4-hydroxy-3-methoxycinnamate, FAEE) has also been widely studied and some recent findings include its anticholinesterase activity; inhibition of nuclear factor-kappa B (NF-κB) activity in LPS-stimulated RAW 264.7 macrophages; inhibition of inducible nitric oxide synthase (iNOS) induction in UV-induced oxidative stress in melanocytes; induction of heme oxygenase (HO-1) activity in rat astrocytes and neurons, which is a putative pathway against oxidative stress that underline neurodegenerative diseases; and cytoprotective effect against reactive oxygen species (ROS)-induced damage through the stimulation of dermal fibroblasts stress response. These potential pharmacological properties of FAEE have been related to its increased lipophilicity compared to its acid precursor, a property that could enhance the accessibility to the intracellular medium by diffusion by the cell membrane.

 

The enhanced pharmacological properties of FAEE compared to FA is not an isolated phenomenon. Indeed, the esterification of phenolic acids has widely been used as an efficient approach to improve its efficacy in several experimental models. A significant example is gallic acid, since the antimutagenicity activity against activated 2-aminoanthracene (2AA)-induced SOS responses in Salmonella typhimurium is dependent on alkyl chain length of the gallic acid alkyl esters. The antioxidant capacity, evaluated as inhibitors of AAPH-induced lyses of erythrocytes was eight-fold higher when propyl gallate was compared to gallic acid. Gallates are also more effective than their acid precursors as inhibitors of TNF-α-induced NFκB activation in human embryonic kidney cells. A similar tendency was observed to protocatechuic and caffeic acids. In this concern, findings in our laboratory have demonstrated that the heptyl ester of protocatechuic acid was ten-fold more efficient that the acid precursor as inhibitor of the production of superoxide in activated neutrophils; and the butyl and heptyl esters of caffeic acid were four-fold more effective as bactericidal agent against Helicobacter pylori.

 

 

Ethyl Ferulate Specification:

 

ItemSpecification
Assay99.0% min
Specific rotation+39.5 to +41.5°
State of solution(transmittance)Clear 98.0% min.
Chloride[cl]0.020% max.
Ammonium [NH4]0.02% max.
Sulfate[SO4]0.020% max
Iron[Fe]10ppm max.
Heavy metals [Pb]10ppm max
Arsenic[As2O3]1ppm max
Other amino acidsChromatographically not detectable
Loss on drying0.20% max.
Residue on ignition[sulfated]0.10% max.

 

 

 

Ethyl Ferulate Test Report:

 

ItemSpecificationResults
Assay(Ferulic acid by HPLC)NLT 99.0 %99.4%
Loss on DryingNMT 5.0%0.42%
Sieve100% pass 100 meshComplies
Melting point173-176ºCConforms
Sulphated AshNMT 0.1%0.04%
Heavy MetalsNMT 10ppmConforms
ArsenicNMT 1ppmConforms
Related SubstancesNMT 0.5%0.23%
Residual SolventEur.PharmConforms
Total plate count<1000/ g120/g
Yeast & mold<100/ g30/g
E.coilNegativeNegative
SalmoneliaNegativeNegative

 

 

Competitive advantages

1) As a leading manufacture, Our products have been exported to Norway, Poland, Finland, Spain, UK, France, Germany, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
2) We offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best after-sale service is our philosophy.
3) We have Flexible and Untraceable payment terms.

 


Delivery and Packing

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Professional and Well trained Packing Team
Prompt delivery, In 24 hours delivery after payment

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24/7 after sale service.

 

 

 

 

 

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FlibanserinBoldenone UndecylenatePT-141 (brmelanotice)
 Oxandrolone(Anavar)Gonadorelin Acetate
RimonabantStanozololHexarelin Acetate
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T3Metenolone acetateMGF
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IsotretinoinClomifeneDSIP
PregabalinOstarine MK-2866Pentadecapeptide BPC 157
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