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Procaine hydrochloride Procaine HCl 51-05-8 with Safe Pass Customs

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Procaine hydrochloride Procaine HCl 51-05-8 with Safe Pass Customs

Country/Region china
City & Province wuhan hubei
Categories Plastic Raw Materials

Product Details

Procaine hydrochloride Procaine HCl 51-05-8 with Safe Pass Customs

 

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Procaine HCl Profile

 

Product nameProcaine hydrochloride
Other NameProcaine HCl
CAS51-05-8
M.FC13H20N2O2. HCl
M.W272.77
Assays≥ 99.00
AppearanceWhite crystalline powder
Melting point154degree~157degree
AcidityPH=5.9
Loss on drying0.07%

 

Procaine HCl Description


This product is white crystalline or crystalline powder; odorless, slightly bitter taste, followed by a sense of numbness. This product is soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. The melting point of the product is 154 ~ 157 ℃.

 

Procaine hydrochloride in the role of peripheral nerve conduction block, relying on the concentration gradient to diffuse through the nerve cell membrane, in the medial block of sodium channels, the nerve cell excitatory threshold increases, loss of excitability and conduction, information Transmission is blocked, has a good local anesthetic effect.

 

Dosage for infiltration anesthesia, the solution concentration of 0.25% to 0.5%, the amount of 0.05 ~ 0.25g per hour can not exceed 1.5g. For spinal anesthesia, an amount not more than 0.15g, with 5% solution. For local limbs, intravenous anesthesia, 0.5% solution 40 ~ 150ml. Nerve block with 1% to 2% solution, 1 not more than 1g.

 

Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically .

 

It acts mainly by being a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

 

Procaine HCl Application

 

Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine.

 

Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.

 

Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited.

 

The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

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