Procaine hydrochloride Procaine HCl 51-05-8 with Safe Pass Customs
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Procaine HCl Profile
|Product name||Procaine hydrochloride|
|Other Name||Procaine HCl|
|Appearance||White crystalline powder|
|Loss on drying||0.07%|
Procaine HCl Description
This product is white crystalline or crystalline powder; odorless,
slightly bitter taste, followed by a sense of numbness. This
product is soluble in water, slightly soluble in ethanol, slightly
soluble in chloroform, almost insoluble in ether. The melting point
of the product is 154 ~ 157 ℃.
Procaine hydrochloride in the role of peripheral nerve conduction
block, relying on the concentration gradient to diffuse through the
nerve cell membrane, in the medial block of sodium channels, the
nerve cell excitatory threshold increases, loss of excitability and
conduction, information Transmission is blocked, has a good local
Dosage for infiltration anesthesia, the solution concentration of
0.25% to 0.5%, the amount of 0.05 ~ 0.25g per hour can not exceed
1.5g. For spinal anesthesia, an amount not more than 0.15g, with 5%
solution. For local limbs, intravenous anesthesia, 0.5% solution 40
~ 150ml. Nerve block with 1% to 2% solution, 1 not more than 1g.
Procaine is a local anesthetic drug of the amino ester group. It is
used primarily to reduce the pain of intramuscular injection of
penicillin, and it is also used in dentistry. Owing to the ubiquity
of the trade name Novocain, in some regions procaine is referred to
It acts mainly by being a sodium channel blocker. Today it is used
therapeutically in some countries due to its sympatholytic,
anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl Application
Procaine is an anesthetic agent indicated for production of local
or regional anesthesia, particularly for oral surgery. Procaine
(like cocaine) has the advantage of constricting blood vessels
which reduces bleeding, unlike other local anesthetics like
Procaine is an ester anesthetic. It is metabolized in the plasma by
the enzyme pseudocholinesterase through hydrolysis into
para-aminobenzoic acid (PABA), which is then excreted by the
kidneys into the urine.
Procaine acts mainly by inhibiting sodium influx through voltage
gated sodium channels in the neuronal cell membrane of peripheral
nerves. When the influx of sodium is interrupted, an action
potential cannot arise and signal conduction is thus inhibited.
The receptor site is thought to be located at the cytoplasmic
(inner) portion of the sodium channel. Procaine has also been shown
to bind or antagonize the function of N-methyl-D-aspartate (NMDA)
receptors as well as nicotinic acetylcholine receptors and the
serotonin receptor-ion channel complex.
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