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Oxaliplatin Injection Medicine 50mg / 100mg Stage III Antineoplastic Agents Advanced Colorectal Cancer Treatment

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Oxaliplatin Injection Medicine 50mg / 100mg Stage III Antineoplastic Agents Advanced Colorectal Cancer Treatment

Country/Region china
City & Province hubei
Categories Dyestuffs

Product Details

Oxaliplatin for injection 50mg/100mg antineoplastic agent treatment of stage III colon cancer&advanced colorectal cancer

Compostion

Oxaliplatin is supplied in clear, glass, single-use vials with gray elastomeric stoppers and aluminum flip-off seals containing 50 mg or 100 mg of oxaliplatin as a sterile, preservative-free, aqueous solution at a concentration of 5 mg/mL. Water for Injection, USP is present as an inactive ingredient.

Description:

 

Oxaliplatin injection is an antineoplastic agent with the molecular formula C8H14N2O4Pt and the chemical name of cis-[(1 R,2 R)-1,2-cyclohexanediamine-N,N'] [oxalato(2)-O,O'] platinum. Oxaliplatin is an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane(DACH) and with an oxalate ligand as a leaving group .

The molecular weight is 397.3. Oxaliplatin is slightly soluble in water at 6 mg/mL, very slightly soluble in methanol, and practically insoluble in ethanol and acetone.

 

Oxaliplatin is supplied in vials containing 50 mg or 100 mg of oxaliplatin as a sterile, preservative-free, aqueous solution at a concentration of 5 mg/mL. Water for Injection, USP is present as an inactive ingredient.

 

Indications

 

Oxaliplatin, used in combination with infusional 5-fluorouracil/leucovorin, is indicated for:

  • adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.
  • treatment of advanced colorectal cancer.

 

Dosage

 

Administer Oxaliplatin in combination with 5-fluorouracil/leucovorin every 2 weeks. For advanced disease, treatment is recommended until disease progression or unacceptable toxicity. For adjuvant use, treatment is recommended for a total of 6 months (12 cycles):

 

Day 1: Oxaliplatin 85 mg/m² intravenous infusion in 250-500 mL 5% Dextrose injection, USP and leucovorin 200 mg/m² intravenous infusion in 5% Dextrose Injection, USP both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-fluorouracil 400 mg/m² intravenous bolus given over 2-4 minutes, followed by 5-fluorouracil 600 mg/m² intravenous infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a 22-hour continuous infusion.

 

Day 2: Leucovorin 200 mg/m² intravenous infusion over 120 minutes, followed by 5-fluorouracil 400 mg/m² intravenous bolus given over 2-4 minutes, followed by 5-fluorouracil 600 mg/m² intravenous infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a 22-hour continuous infusion.

 

Side effects

 

Some people receiving a oxaliplatin injection have had a reaction to the infusion within minutes after the medicine is injected into the vein. Tell your caregiver right away if you feel dizzy, short of breath, confused, sweaty, itchy, or have diarrhea, chest pain, warmth or redness in your face, or feel like you might pass out.

 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • headache, confusion, change in mental status, vision problems, seizure (convulsions);
  • numbness, tingling, or burning pain that interferes with daily activities;
  • increased sensitivity to cold temperatures and cold objects;
  • jaw or chest tightness, eye pain, strange feeling in your tongue, problems with speech or swallowing;
  • fever, chills, sore throat, mouth and throat ulcers, cough with mucus;
  • dry cough, wheezing, feeling short of breath on exertion;
  • pain or burning when you urinate;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • pale skin, feeling weak or tired, rapid heart rate, trouble concentrating;
  • pain, redness, swelling, or skin changes where the injection was given; or
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Other common side effects may include:

  • nausea, vomiting, stomach pain, loss of appetite;
  • diarrhea, constipation;
  • weight gain;
  • muscle pain; or
  • temporary hair loss.

Storage:

 

Store at 25°C ,excursions permitted to 15-30°C Do not freeze and protect from light (keep in original outer carton).

 

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