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Nuciferine is an alkaloid found within the plants Nymphaea caerulea
and Nelumbo nucifera.
It has a profile of action associated with dopamine receptor
blockade. It induces sedation, hypothermia, ptosis, and (in higher
doses) catalepsy; it inhibits spontaneous motor activity,
conditioned avoidance response, amphetamine toxicity and
stereotypy. Nuciferine may also potentiate morphine analgesia. The
median lethal dose in mice is 289 mg/kg. It is structurally related
to apomorphine.
Application-nervous systerm-sedation, hypothermia, ptosis, and (in
higher doses) catalepsy.
