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Product name: Hydroxylamine hydrochloride / hydroxylamine HCl
CAS No.: 5470-11-1
MF: ClH4NO
EINECS No.: 226-798-2
Purity: 99% min
MW: 69.49
Hydroxylamine Hydrochloride is the hydrochloric acid salt of hydroxylamine. Hydroxylamine is a biological intermediate in the nitrification (biological oxidation of ammonia with oxygen into nitrite) and in the anammox (biological oxidation of nitrite and ammonium into dinitrogen gas) which are important in the nitrogen cycle in soil and in wastewater treatment plants.
Item | Spec 1 | Spec 2 | Spec 3 |
Appearance | White crystal | White crystal | White crystal |
Content % ≥ | 98.00 | 99.00 | 99.00 |
Moisture % ≤ | 0.40 | 0.30 | 0.30 |
Sulphate % ≤ | 0.02 | 0.005 | 0.003 |
Fe % ≤ | 0.0005 | 0.0003 | 0.0003 |
Heavy metal% ≤ | 0.0005 | 0.0003 | 0.0003 |
1) Hydroxylamine and its salts are commonly used as reducing agents in myriad organic and inorganic reactions. They can also act as antioxidants for fatty acids.
2) Conversion from cyclohexanone to caprolactam involving the Beckmann Rearrangement can be understood with this scheme.
3) In the synthesis of nylon 6, cyclohexanone is first converted to its oxime; treatment of this oxime with acid induces the Beckmann rearrangement to give caprolactam :
The nitrate salt, hydroxylammonium nitrate, is being researched as a rocket propellant, both in water solution as a monopropellant and in its solid form as a solid propellant.
4) This has also been used in the past by biologists to introduce random mutations by switching base pairs from G to A, or from C to T. This is to probe functional areas of genes to elucidate what happens if their functions are broken. Nowadays other mutagens are used.
5) Hydroxylamine can also be used to highly selectively cleave asparaginyl-glycine peptide bonds in peptides and proteins. It also bonds to and permanently disables (poisons) heme-containing enzymes. It is used as an irreversible inhibitor of the oxygen-evolving complex of photosynthesis on account of its similar structure to water.
6) This route also involves the Beckmann Rearrangement, like the
conversion from cyclohexanone to caprolactam.
An alternative industrial synthesis of paracetamol developed by
Hoechst–Celanese involves the conversion of ketone to a ketoxime
with hydroxylamine.