Home Companies Guangzhou Huao Chemical Co.,Ltd

Pharmaceutical Raw Materials AZD3759 Powder for Cancer treatment 1626387-80-1

Contact Us

[China]

Trade Verify

Address: Room 1102 1 Unit 16 building South time NANSHA district ,Guangzhou,Guangdong ,China.

Contact name:Adam

Guangzhou Huao Chemical Co.,Ltd

Verified Suppliers
  • Trust
    Seal
  • Verified
    Supplier
  • Credit
    Check
  • Capability
    Assessment

Pharmaceutical Raw Materials AZD3759 Powder for Cancer treatment 1626387-80-1

Country/Region china
City & Province guangzhou guangdong
Categories Flavour and Fragrance

Product Details

99% Purity AZD3759 Powder for Cancer treatment 1626387-80-1

Basic infors:
English name: AZD 3759
English Synonyms: AZD 3759; AZD3759; AZD-3759; (2R) -2,4-Dimethyl- 1-piperazinecarboxylic acid 4 - [(3-chloro-2- fluorophenyl) amino] HY-18750; azd3579;
CAS number: 1626387-80-1
Molecular formula: C22H23ClFN5O3
Molecular weight: 459.91

AZD3759 description

AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del, . AZD3759 inhibits EGFR phosphorylation with IC50 of 7.2 nM. AZD3759 showed an inhibitory effect on the proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and the EGFR mutant with IC50 of 7.7 nM and 7 nM, respectively, with no activity on the proliferation of H838 cells.
Phase 1 clinical trials of AZD3759 showed very good control activity of intracranial lesions, and the dose of this drug is recommended to be 200 mg or 300 mg twice daily. AZD3759 has no better control of extracranial lesions than the other EGFR-targeted agents, but shows greater control over intracranial lesions.
Patients with meningeal metastases from this clinical trial benefit from the treatment of AZD3759, and the

300 mg dose appears to achieve greater control.



Application
1.Non-small cell lung cancer is one of the major diseases that threaten human health. Even more serious is up to 50% of cancer patients with central nervous system metastasis in their lifetime, metastatic lung cancer is currently no cure. Recently, AstraZeneca's Chinese team led by Dr. Zhang Xiaolin successfully developed a new drug, AZD3759, to treat central nervous system metastases of lung cancer. Their early R & D results have been published in "Journal of Medicinal Chemistry".

2.In order to solve the challenging problem of blood-brain barrier, the author comprehensively optimizes structural parameters such as molecular size, polarity, rigidity and the like, and adjusts various biophysical and chemical properties such as basicity, water solubility, permeability and stability To the best condition to cross the blood-brain barrier. The fully optimized design has successfully brought AZD3759 to the same effective concentrations in different settings of the blood and central nervous system. In addition, the authors also published a preclinical in vitro and in vivo assessment of a subset of candidate compounds. Clinical studies of AZD3759 are underway.


Our advantages:

1.Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.


2. Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.

3.Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand
Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery. Shipment by DHL, TNT, FEDEX, HKEMS, UPS, etc.

Packing?

1. food bag packing

2. according to your suggestion

2. change the name to ship your parcel



 

Hot Products

99% Purity AZD3759 Powder for Cancer treatment 1626387-80-1 Basic infors: English name: AZD 3759 ...
99% purity Mupirocin powder Used to make antibiotics 12650-69-0 English name: Mupirocin English ...
Local Anesthetic Powder tetracaine hydrochloride powder 136-47-0 tetracaine hydrochloride CAS number...
Local Anesthetic Powder lidocaine for Pain release CAS 137-58-6 lidocaine hydrochloride CAS number...
Local Anesthetic Powder benzocaine for Pain release CAS 94-09-7 Benzocaine CAS number:94-09-7 Purity...
Local Anesthetic Powder Dimethocaine/ Larocaine for Pain release 94-15-5 Dimethocaine/ Larocaine CAS ...