99% Assay Oral Anabolic Steroids Oxandrolone Anavar For Body
Building CAS 53-39-4
Oxandrolone, sold under the trademarks Oxandrin and Anavar among
others, is an anabolic steroid that was first available as a
prescription drug in the United States in 1964. It is a synthetic
derivative of dihydrotestosterone with an oxygen atom replacing the
2 carbon and methylation in the 17 position.
Researchers and medical professionals have used oxandrolone to
treat a wide variety of disorders. These include idiopathic short
stature, Turner syndrome, body mass loss from catabolic illness or
long-term corticosteroid treatment, severe burns, surgical or
general trauma, osteoporosis, anemia, hereditary angioedema,
HIV/AIDS-induced wasting, alcoholic hepatitis, and hypogonadism.
Oxandrolone is well-established as a safe treatment for patients
recovering from severe burns. Medical research has also established
oxandrolone's efficacy in aiding the development of girls with
Turner syndrome. Although oxandrolone has long been used to
accelerate growth in children with idiopathic short stature, it is
unlikely to increase adult height and in some cases may even
decrease it. Oxandrolone is has therefore largely been replaced by
growth hormone for this use.
Some bodybuilders use oxandrolone for its muscle-building
properties, usually purchasing it from black market suppliers. This
is illegal in the United States, Canada, the United Kingdom, and
many other countries.
Oxandrolone has been researched and prescribed as a treatment for a
wide variety of conditions. Oxandrolone is FDA-approved for
treating osteoporosis, aiding weight gain, and counteracting the
catabolic effect of long-term corticosteroid treatment.As of 2016,
it is often prescribed off-label to quicken recovery from severe
burns, aid the development of girls with Turner syndrome, and
counteract HIV/AIDS-induced wasting.
Oxandrolone increases both short-term and long-term outcomes in
patients recovering from severe burns. Most evidence shows that it
reduces the amount of time spent hospitalized and that improved
muscle and bone recovery are still measurable a year after injury.
Research suggests that oxandrolone is also effective in the
treatment of alcoholic hepatitis.
Like other anabolic steroids, oxandrolone may worsen hypercalcemia
by increasing osteolytic bone resorption. When taken by pregnant
women, oxandrolone may have unintended effects such as
masculinization on the fetus.
Although some orally-administered anabolic steroids are
hepatotoxic, oxandrolone causes little or no detectable stress to
burn victims' livers at clinical doses.This supports the notion
common among bodybuilders that oxandrolone is less hepatotoxic than
most common oral anabolic steroids.
Women who are administered oxandrolone may experience virilization,
the non-reversible development of masculine features such as voice
deepening, hirsutism, menstruation abnormalities, male-pattern hair
loss, and clitoral enlargement. Oxandrolone may disrupt growth in
children, reducing their adult height. Because of these side
effects, doses given to women and children are chosen carefully and
patients are usually monitored for virilization and growth
Unlike some anabolic steroids, oxandrolone does not generally cause
gynecomastia because it is not aromatized into estrogenic
Like other androgens, oxandrolone can cause or worsen acne and
priapism (unwanted or prolonged erections). Oxandrolone can also
reduce males' fertility, another side effect common among
androgens.In an attempt to compensate for the exogenous increase in
androgens, the body may reduce testosterone production via
testicular atrophy and inhibition of gonadotropic activity.
Oxandrolone greatly increases warfarin's blood-thinning effect,
sometimes dangerously so. In April 2004, Savient Pharmaceuticals
published a safety alert through the FDA warning healthcare
professionals of this. Oxandrolone can also inhibit the metabolism
of oral hypoglycemic agents.It may worsen edema when taken
alongside adrenal cortical steroids or adrenocorticotropic hormone
Like other anabolic steroids, oxandrolone is an androgen receptor
agonist. This increases protein synthesis, which increases muscle
growth, lean body mass, and bone mineral density.
Mechanism of action
Compared to testosterone and most other anabolic steroids,
oxandrolone is less androgenic relative to its strength as an
anabolic. This often motivates its medical use in children and
women because less androgenic effect implies less risk of
virilization. The bodybuilding community also considers this fact
when choosing between steroids.
Children with idiopathic short stature or Turner syndrome are given
doses of oxandrolone far smaller than those given to burn patients.
Researchers have chosen dose ranges for children with great care in
order to minimize the likelihood of virilization and premature
maturation. Most adults treated with oxandrolone receive moderate
doses. Bodybuilders often take doses much higher than
Oxandrolone is generally administered at least once daily.
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Oxandrolone was first made by Raphael Pappo and Christopher J. Jung
while at Searle Laboratories (now part of Pfizer). The researchers
first described the chemical in 1962. They were immediately
interested in oxandrolone's very weak androgenic effect relative to
its anabolic effect. It was released as a pharmaceutical drug in
the United States in 1964.
The drug was prescribed to promote muscle regrowth in disorders
which cause involuntary weight loss, and is used as part of
treatment for HIV/AIDS. It had also been shown to be partially
successful in treating cases of osteoporosis. However, in part due
to bad publicity from its illicit use by bodybuilders, production
of Anavar was discontinued by Searle Laboratories in 1989. It was
picked up by Bio-Technology General Corporation, which changed its
name to Savient Pharmaceuticals who, following successful clinical
trials in 1995, released it under the tradename Oxandrin. BTG
subsequently won approvals for orphan drug status by the Food and
Drug Administration (FDA) for treating alcoholic hepatitis, Turner
syndrome, and HIV-induced weight loss. It is also indicated as an
offset to protein catabolism caused by long-term administration of
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