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The cysteine proteinase inhibitor (CPI) is known as cystatin C. Cycle in inhibition of C is cleared after the glomerular filtration, only is a kind of endogenous markers to reflect the actual changes in glomerular filtration rate, and in the proximal convoluted tubule reuptake, but were completely after heavy absorption metabolism decomposition, do not return the blood, therefore, its blood concentration is determined by glomerular filtration rate, and not dependent on any external factors, such as gender, age, diet, It is an ideal endogenous marker to reflect the change of glomerular filtration rate.
Detection range | sample size | Sample type | Test time |
0.2~8mg/L | 10μl | Whole blood / serum / plasma | 15min |
Cystatin C | Cystatin C | ||||
creatinine | |||||
GFR(mL/min/1.73m2) | >89 | 60-89 | 30-59 | 15-29 | <15 |
CKD stage | 1 | 2 | 3 | 4 | 5 |
Renal impairment with normal/elevated GFR | Mild renal insufficiency | Moderate renal insufficiency | Severe renal insufficiency | Stage Renal Disease (ESRD) |
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