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Luteinizing hormone (LH) is a kind of glycoprotein gonadotropin secreted by basophil cells of anterior pituitary. It mainly promotes ovulation, forms corpus luteum and secretes progesterone under the synergistic effect of FSH. In general, the normal value in non ovulation period is 5-25 mIU / ml, lower than 5 mIU / ml indicates insufficient gonadotropin function, which is seen in Sheehan's syndrome. High FSH plus high LH indicates ovarian function decline, and LH / FSH ≥ 3 is one of the basis for the diagnosis of polycystic ovary syndrome.
Detection range | sample size | Sample type | Test time |
0.2~160mIU/mL | 60μl | Whole blood / serum / plasma | 15min |
Corresponding items | index | Guiding significance | |
FSH,LH | ↑ | Common in primary gonadal lesions | Such as premature ovarian failure, gonadal hypoplasia, primary amenorrhea, primary sexual dysfunction, seminiferous tubule development disorders, complete (true) precocious puberty. |
↓ | It is mainly seen in pituitary or hypothalamic amenorrhea, incomplete (pseudo) precocious puberty. | ||
Pituitary FSH tumor or LH tumor | The concentration of FSH and LH changed in different types of tumors | FSH tumor mainly showed increased FSH and normal LH; In patients with LH tumor, LH increased significantly and FSH decreased; | Both FSH and LH were increased in FSH / LH tumors. |
Concentration of FSH and LH in amenorrhea women | To differentiate ovarian amenorrhea from pituitary or hypothalamic amenorrhea |
Gynecology, obstetrics, laboratory, oncology, reproductive medicine, genetics, etc
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